She had a long and productive stage career, and appeared in more than 100 films from 1911 to 1950. She played Aunt Polly in Huckleberry Finn (1931), and Miss Watson in The Adventures of Huckleberry Finn (1939). She was paid $750 for her work on the Oz film.
Over her career, Blandick had varied experience with her Oz castmates. She appeared:
- with Frank Morgan in Sisters Under the Skin (1934) and Keys to the City (1950)
- with Jack Haley in People are Funny (1946)
- with Charley Grapewin in three films in the mid-1930s
- with Margaret Hamilton in three films from 1934 to 1950.
Blandick committed suicide at the age of 81 with a dose of sleeping pills, after a long period of poor health and failing eyesight.